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2D DNA NANONETWORKS
DNA nanotechnology is the fairly new field of research that deals
with the construction of nanonetworks from smaller DNA components.
Normally, dsDNA does not branch in vivo except as intermediate structures.
However, it is possible to build 2D or 3D networks of DNA that can
be used to position other molecules or molecular mechanical devices
with high spatial precision. These nanonetworks can be used in nanorobotic
devices, nanosensors, and nanomaterials.
Assembly of dsDNA is based on predictable and well-controlled base
pair interactions. As a result, it is relatively easy to control
the composition, organization and the binding properties of DNA-based
materials making it an optimal material for all applications above.
Thus far, most DNA networks have been constructed using tiles, or
large pieces of DNA. However, we are attempting to use small, single-stranded
oligonucleotides in order to facilitate faster self-assembly and
smaller features within the structure. Smaller features would benefit
certain applications of these nanostructures including the positioning
of enzymatic cascades and nanocircuits. We are using commercially
synthesized oligonucleotides in order to assemble 2D nanonetworks.
Our results are first analyzed with agarose gel electrophoresis
and then visualized using the Atomic Force Microscopy.
View
final presentation as PDF
See
final presentation video (23.0 MB)
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